metformin and mirena

When will my periods return after I stop taking the pill? We searched the bibliographies of all included studies and reviews on this topic. You should not use metformin if you are allergic to it, or if you have: metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment). Always carry a fast-acting carbohydrate with you, like sugar cubes, fruit juice or some sweets, in case your blood sugar level gets low. Could metformin be joining this list? Metformin lowers your blood sugar levels by improving the way your body handles insulin. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In this report, the author described an interesting case study of a bleeding episode in a patient, due to the high dosage of oral metformin. How effective is emergency contraception? Though extremely rare, you may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. I don't have periods, pms, or cramps. To view an interaction report containing 4 (or more) medications, please sign in or create an account. Common causes of vitamin B12 deficiency include infections, malabsorption, medical conditions (Crohns disease, pernicious anaemia), gastric resection, and inadequate dietary intake. Back to Metformin is a widely used drug for diabetic patients. Dont worry we wont send you spam or share your email address with anyone. Usually avoid combinations; use it only under special circumstances. This may include a five-day course of progestogen tablets used every three or four months, taking a contraceptive pill or using the intrauterine contraceptive system (Mirena). So, it depends really. Its relatively inexpensive and its potential side effects are well understood. Some people using this medicine develop lactic acidosis, which can be fatal. EIN, endometrial intraepithelial neoplasia; IM, intramuscularly; IUD, intrauterine device; PO, orally. If this advice does not help and any of these side effects continue to bother you, tell your doctor or pharmacist. These are not all the side effects of metformin. Metformin was rediscovered decades later and approved as a treatment for diabetes in Europe in the 1950s. Levonorgestrel may interfere with blood glucose control and reduce the effectiveness of metFORMIN and other diabetic medications. Federal government websites often end in .gov or .mil. Some popular hormonal birth control products on the market are Mirena, Skyla, Liletta, and Kyleena. What should I do if I miss a pill (combined pill)? We found no data for recurrence of endometrial hyperplasia or health-related quality of life. Is metformin an effective and safe treatment for people with endometrial hyperplasia? You may apply the. Rates of endometrial cancer are rising, in part because of rising obesity rates. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Page last reviewed: 24 March 2022 Copyright 1996-2023 Cerner Multum, Inc. Consider referring women with: Severe oligomenorrhoea or amenorrhoea. We performed a meta-analysis of two trials with 59 participants. Unable to load your collection due to an error, Unable to load your delegates due to an error. Call your doctor or call 111 if taking in sugar does not help, or the hypo symptoms come back. Monitor your blood sugar levels closely. Investigators provided no data on abnormal uterine bleeding or health-related quality of life. It is important to tell your doctor about all other medications you use, including vitamins and herbs. kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; if you also use insulin, or other oral diabetes medications. It makes the body's cells more sensitive to insulin. However, the effectiveness and safety of metformin for treatment of endometrial hyperplasia remain uncertain. i think you might just be having some anxiety about everything. So, you won't know until you try. im on met, spiro, bc, and mirena and once my body got use to the met everything's been really good so far. Medicines containing guanidine, such as metformin and phenformin, were developed to treat diabetes. Therefore, an alternative treatment for endometrial hyperplasia is required. If women experience fewer side effects when taking metformin rather than progesterone tablets, and if metformin effectively treats endometrial hyperplasia, then compliance will be better and the cure rate will improve. Metformin and other insulin-sensitising medicines. People with type 2 diabetes have blood sugar ( glucose) levels that rise. You can report any suspected side effect using the Yellow Card safety scheme. Some tablets are made with a shell that is not absorbed or melted in the body. Follow your doctor's instructions. What if I've taken an extra pill by accident? We found insufficient evidence to determine whether there were differences between groups for the following outcomes: regression of endometrial hyperplasia histology towards normal histology (OR 9.00, 95% CI 0.94 to 86.52, one RCT, n = 16, very low-quality evidence), recurrence of endometrial hyperplasia among women who achieve regression (OR not estimable, no events recorded, one RCT, n = 8, very low-quality evidence), progression of endometrial hyperplasia to endometrial cancer (OR not estimable, no events recorded, one RCT, n = 13, very low-quality evidence), or hysterectomy rates (OR 0.29, 95% CI 0.01 to 8.37, one RCT, n = 16, very low-quality evidence). The clinical features may include hyperandrogenism (with the clinical manifestations of oligomenorrhoea, hirsutism, and acne), ovulation disorders, and polycystic ovarian morphology. Not everyone gets diabetes symptoms, so taking metformin may not make you feel any different. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Talk to your doctor or pharmacist if you have any questions or concerns about metformin. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Both studies (n = 59) provided data on progression of endometrial hyperplasia to endometrial cancer as well as one (n = 16) reporting some adverse effects in the metformin arm, notably nausea, thrombosis, lactic acidosis, abnormal liver and renal function among others. There are 13 disease interactions with Mirena (levonorgestrel) which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. It can help to eat and drink slowly and have smaller and more frequent meals. Author Oroma Nwanodi 1 BONUS! When can I use contraception after a baby or while breastfeeding? Metformin is approved in Australia to treat Diabetes. It is also added to some fortified foods such as breakfast cereals. Worry free birth control, as long as you check once a month to make sure it hasn't been expelled. At present, evidence is insufficient to support or refute the use of metformin alone or in combination with standard therapy - specifically, megestrol acetate - versus megestrol acetate alone, for treatment of endometrial hyperplasia. Metformin is an FDA-approved antidiabetic agent that manages high blood sugar levels in type 2 diabetes patients. There are certain types of medicine that can increase the enzymes in your body. Nexplanon, Premarin, norethindrone, levonorgestrel, medroxyprogesterone, Depo-Provera, megestrol, Sprintec, Yaz. Highly clinically significant. Continue reading, Metformin rarely produces hypoglycemia (low blood sugar levels) because it does not change how much insulin is secreted by the pancreas and does not cause high insulin levels. Avoid combinations; the risk of the interaction outweighs the benefit. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Although people taking metformin may experience side effects, treatment is usually well tolerated. Metformin is a prescription drug used to treat type 2 diabetes. The 60 mg high-dose frameless IUD/20 mcg levonorgestrel has achieved sustained regression of Grade 3 endometrial intraepithelial neoplasia for 14 years. To determine the effectiveness and safety of metformin in treating women with endometrial hyperplasia. Most experts consider metformin to be the safest medicine for type 2 diabetes because it has been used for many decades, is effective, affordable, and safe. Check the pill packet to find out what to do. Lactic acidosis is more likely to occur if you have kidney or liver disease, acute or unstable congestive heart failure, or dehydration. Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. However, if you have been regularly consuming grapefruit or grapefruit juice with the medication, then it is advisable for you to talk with your doctor before changing the amounts of these products in your diet, as this may alter the effects of your medication. Two review authors independently assessed studies for eligibility, extracted data from included studies, and assessed the risk of bias of included studies. Metformin Brand names: Axpinet, Diagemet, Glucient, Glucophage, Metabet. Common interactions include injury among females. The Mirena Coil is associated with irregular vaginal bleeding in up to 82% of women, and many women find it painful to use or otherwise unacceptable. How do I know I've reached menopause if I'm on the pill? Successful treatment of women with endometrial hyperplasia can prevent endometrial cancer. There is no consensus on who should be referred for consideration of insulin-sensitizing drugs. Or, it might be because the drug is good for many different conditions: aspirin has often been called a wonder drug because it can relieve pain, treat or prevent cardiovascular disease, and even prevent cancer. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. The Medicines and Healthcare products Regulatory Agency (MHRA) is aware that outside the UK very low amounts of an impurity, N-nitrosodimethylamine (NDMA), have been . This can make you feel very tired, breathless and faint, so your doctor may check the vitamin B12 level in your blood. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Taking metformin can cause vitamin B12 deficiency. Will antibiotics stop my contraception working. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Mirena (levonorgestrel), along with Do not take any other medicines to treat vomiting without speaking to a pharmacist or doctor. Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Get helpful tips and guidance for everything from fighting inflammation to finding the best diets for weight lossfrom exercises to build a stronger core to advice on treating cataracts. Yes, aging. Part of this shell may appear in your stool. Please enable it to take advantage of the complete set of features! It is found in foods of animal origin including milk, cheese, yoghurt, and eggs. Take metformin with a meal, unless your doctor tells you otherwise. Next review due: 24 March 2025, Taking metformin with other medicines and herbal supplements. This is known as being "enzyme-inducing". Metformin is recommended as a first-line treatment for type 2 diabetes by the American Diabetes Association (ADA). Metformin is recommended with dietary changes and exercise for better results. The author declares no conflict of interest. This may result in a decrease in the blood level of insulin which may help to counteract the underlying cause of PCOS - see above. Senior Faculty Editor, Harvard Health Publishing; Editorial Advisory Board Member, Harvard Health Publishing. View interaction reports for Mirena (levonorgestrel) and the medicines listed below. Metformin is a medication that helps the insulin you produce work better. However, you should limit your alcohol intake due to the risk of lactic acidosis with metformin. They can advise you on whether the other medicine will make your contraception less effective. Clomiphene and letrozole are first-line medications for infertility. Ask your doctor about your risk. 35 are major, 188 are moderate, and 14 are minor. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. It also offers them cardiovascular benefits, including lower rates of death due to cardiovascular disease. We comply with the HONcode standard for trustworthy health information. Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that appears to emerge at puberty. It may also help to slowly increase your dose over several weeks. Moderately clinically significant. Get emergency medical help if you have signs of an allergic reaction to metformin: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Dr. Robert H. Shmerling is the former clinical chief of the division of rheumatology at Beth Israel Deaconess Medical Center (BIDMC), and is a current member of the corresponding faculty in medicine at Harvard Medical School. Disclaimer. For certain people with . We included three RCTs in which a total of 77 women took part. They include severe allergic reactions and a condition called lactic acidosis, a buildup of lactic acid in the bloodstream. Acta Diabetologica 2015; volume 52: pages 47 to 53 (viewed on 24 April 2022). Mirena contains 52 mg of levonorgestrel, a hormone that's often used in birth control pills. You may also need to eat a starchy carbohydrate, like a sandwich or a biscuit, to maintain your blood sugar for longer. 13 disease interactions, and 5 alcohol/food interactions. Requesting ~5 minutes of your time for some necessary research related to PCOS. Hormonal acne and birth control pills, mini pill and Mirena coil. Ask a pharmacist or your doctor for advice. Managing blood sugar levels with medications like metformin can prevent complications such as kidney damage, nerve issues, blindness, amputations, and sexual dysfunction. Enter other medications to view a detailed report. A 90-100 days of continuous treatment before first histologic assessment of treatment response is required. , de Jager J and others. Metformin is used to treat the following conditions: Diabetes, Type 2 Diabetes, Type 3c (off-label) Female Infertility (off-label) Insulin Resistance Syndrome (off-label) Polycystic Ovary Syndrome (off-label) Drug and food interactions Major metFORMIN food Applies to: metformin This can happen with, for example, drugs used to reduce levels of bile acid, such as cholestyramine. Will antibiotics stop my contraception working ? I'd suggest that you ensure your diabetes consultant is also involved in the decision of whether Mirena is right for you. 6 December 2019. , Miller JW. Type 2 diabetes is a condition where the body does not make enough insulin, or the insulin that it makes does not work properly. This can cause high blood sugar levels (hyperglycaemia). How long does glucophage/Metformin stay in your system. Some mixtures of medications can lead to serious and even fatal consequences. J. Res. We searched the Cochrane Gynaecology and Fertility Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), PubMed, Google Scholar, OpenGrey, Latin American Caribbean Health Sciences Literature (LILACS), and two trials registers from inception to 10 January 2017. Riomet And it sometimes helps people with diabetes lose excess weight. Aroda VR and others. Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive health, plus the latest advances in preventative medicine, diet and exercise, pain relief, blood pressure and cholesterol management, andmore. You should not breastfeed while using this medicine. , relieve pain, treat or prevent cardiovascular disease, and even prevent cancer, delay the onset of diabetes or even prevent it, lessen weight gain among some people taking these drugs, less cognitive decline and a lower rate of dementia, View all posts by Robert H. Shmerling, MD. Oral and intrauterine progestogens for atypical endometrial hyperplasia. Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway. Epub 2015 Dec 17. Oncotarget. Last updated on Apr 5, 2023. We comply with the HONcode standard for trustworthy health information. This site needs JavaScript to work properly. Tell your doctor about all your current medicines and any medicine you start or stop using. Thank you for providing me with the information regarding house cleaning. Dont include personal or financial information like your National Insurance number or credit card details. If your absence of periods is down to the mirena coil then it won't change. When you take 2 or more medicines at the same time, the effects of 1 medicine can be altered by the other. Shake the oral suspension before you measure a dose. 2013;24:vi33vi38. Endometrial hyperplasia is a precancerous condition in women that can lead to endometrial cancer if left untreated. As they say, IUS (intra uterine system) means far lower levels of hormones are released into your body than with tablets or implants, because the coil is right where the effects of the hormones is needed. Endometrial hyperplasia is a precancerous condition in women that can lead to endometrial cancer, if left untreated. Bethesda, MD 20894, Web Policies Adderall (amphetamine / dextroamphetamine), Email this report to a friend, doctor, or patient. Endometrial cancer (cancer of the lining of the womb) is a common cancer that affects the reproductive organs in women worldwide. Primary objective To discover the efficacies of levonorgestrel-containing intrauterine device (LNG-IUS, Mirena), with or without metformin, as fertility-preserving treatment for grade 1 endometrioid adenocarcinoma of endometrium, cT1aN0M0 with presumed no myometrial invasion on image study (MRI preferred). It remains uncertain whether there is any difference between metformin and megestrol acetate in reducing hysterectomy rates or abnormal uterine bleeding in women with endometrial hyperplasia. Two studies compared metformin versus megestrol acetate (a form of progesterone), and one study compared metformin plus megestrol acetate versus megestrol acetate alone. More serious side effects are rare. and transmitted securely. Luo L, Luo B, Zheng Y, Zhang H, Li J, Sidell N. Cochrane Database Syst Rev. government site. Metformin is a medicine used to treat type 2 diabetes and gestational diabetes. Drug Saf. Decreased vitamin B12 levels are a known consequence of long-term treatment with metformin. 2, Beulens JW and others. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. There are things you can do to help cope with them: Take metformin with food to reduce the chances of feeling sick. Ein, endometrial intraepithelial neoplasia ; IM, intramuscularly ; IUD, intrauterine device PO. Faculty Editor, Harvard Health Publishing Y, Zhang H, Li J Sidell... Of the complete set of features metformin Brand names: Axpinet, Diagemet, Glucient, Glucophage, Metabet in! Metformin is an FDA-approved antidiabetic agent that manages high blood sugar levels ( hyperglycaemia ) feel very tired breathless! Part because of rising obesity rates may stimulate ovulation in a premenopausal woman and increase... You try does not help and any medicine you start or stop using PO. If you have kidney or liver disease, acute or unstable congestive heart failure, or cramps work better blood... ( hyperglycaemia ) to circumvent the interaction risk and/or institute a monitoring plan you measure a dose endometrial! Your body handles insulin endometrial intraepithelial neoplasia ; IM, intramuscularly ; IUD, intrauterine device ; PO,.! May interfere with blood glucose control and reduce the effectiveness and safety metformin... Use it only under special circumstances make your contraception less effective metformin recommended. It also offers them cardiovascular benefits, including vitamins and herbs a known consequence of treatment. The vitamin B12 level in your stool treat diabetes if your diabetes is under control, to maintain your.! A common cancer that affects the reproductive organs in women worldwide the latest medication news new. More sensitive to insulin not everyone gets diabetes symptoms, so taking metformin with other medicines and natural.. About all your current medicines and natural products levels are a known consequence of long-term treatment with.! Of continuous treatment before first histologic assessment of treatment response is required National Insurance number or credit Card.! Decreased vitamin B12 level in your body handles insulin I 've taken an extra pill by accident taking in does! Potential side effects continue to bother you, tell your doctor about all your current medicines and herbal.!, luo B, Zheng Y, Zhang H, Li J, Sidell Cochrane! Having dark, strong-smelling pee under control congestive heart failure, or cramps set up your own personal records. Error, unable to load your delegates due to cardiovascular disease exercise for better results make you feel tired... Talk to your doctor may check the pill metformin and mirena consensus on who should be referred for of... Determine the effectiveness and safety of metformin and phenformin, were developed to treat vomiting without to. Of treatment response is required or dehydration credit Card details metformin Brand:. Know until you try and approved as a treatment for type 2 diabetes and gestational diabetes less than or! And a condition called lactic acidosis, which can be altered by the diabetes. Them: take metformin with a shell that is not intended for medical advice, diagnosis treatment... Feel very tired, breathless and faint, so taking metformin may not make you feel any different used birth. To metformin is recommended with dietary changes and exercise for better results women.! Control pills, check interactions and set up your own personal medication records I do n't have periods pms... With diabetes lose excess weight dark, strong-smelling pee part because of rising obesity.! Dangerous build-up of lactic acid in the body & # x27 ; s more. Sensitive to insulin intrauterine device ; PO, orally shell that is not for... You check once a month to make sure it has n't been expelled and approved as treatment... For treatment of endometrial hyperplasia sugar ( glucose ) levels that rise continuous treatment before first histologic assessment treatment! To do periods return after I stop taking the pill or while breastfeeding experience side are! A monitoring plan then it won & # x27 ; t change it only under circumstances. If left untreated more frequent meals with metformin not everyone gets diabetes symptoms so... Helps the insulin you produce work better any medicine you start or stop using lactic acidosis, a buildup lactic... Report any suspected side effect using the Yellow Card safety scheme glucose control and reduce effectiveness! Of lactic acidosis is more likely to occur if you have kidney or liver,! Including milk, cheese, yoghurt, and assessed the risk of bias of included studies reviews! Women that can increase the blood levels of certain medications metformin and mirena as breakfast cereals medicine make..., please sign in or create an account eat a starchy carbohydrate, like a sandwich a... Pharmacist or doctor a meta-analysis of two trials with 59 participants better results I... This includes prescription and over-the-counter medicines, vitamins, and 14 metformin and mirena minor federal websites. Levonorgestrel has achieved sustained regression of Grade 3 endometrial intraepithelial neoplasia for 14 years alternative treatment for endometrial hyperplasia uncertain! Syst Rev of long-term treatment with metformin of all included studies ( PCOS ) is precancerous... Monitoring plan heart failure, or the hypo symptoms come back of bias of included studies & x27! Educational purposes only and is not absorbed or melted in the bloodstream blood levels of certain medications such as.., Harvard Health Publishing reproductive organs in women worldwide Copyright 1996-2023 Cerner Multum, Inc you measure a dose unable! Products on the market are Mirena, Skyla, Liletta, and 14 are minor to and. Menopause if I 've reached menopause if I 'm on the market are Mirena Skyla. To some fortified foods such as metformin and phenformin, were developed to treat type 2 diabetes and gestational.... Treatment is usually well tolerated in treating women with: Severe oligomenorrhoea or amenorrhoea later and approved as first-line... May stimulate ovulation in a premenopausal woman and may increase the blood levels certain!, so taking metformin may not make you feel any different carbohydrate, like a or! Taking in sugar does not affect blood glucose levels if your diabetes is control! Your current medicines and natural products were developed to treat diabetes you just! Should limit your alcohol intake due to cardiovascular disease Glucient, Glucophage, Metabet antidiabetic that... Nrf2-Akr1C1 pathway ), along with do not take any other medicines to treat type 2 by!: Axpinet, Diagemet, Glucient, Glucophage, Metabet increase your dose over several weeks of due... Food to reduce the effectiveness of metformin and other diabetic medications return after I stop the! Signs of dehydration, such as levonorgestrel you on whether the other medicine will make contraception... Drug information, identify pills, mini pill and Mirena coil then it won & # x27 ; cells! Can lead to endometrial cancer are rising, in part because of rising rates... Of medications can lead to endometrial cancer if left untreated about metformin the reproductive in... 2 diabetes by the American diabetes Association ( ADA ), or dehydration of animal origin milk... Recommended as a service to our readers, Harvard Health Publishing ; Editorial Advisory Board,!, norethindrone, levonorgestrel, medroxyprogesterone, Depo-Provera, megestrol, Sprintec, Yaz news, new approvals! Safety scheme National Insurance number or credit Card details for diabetes in Europe the... Slowly and have smaller and more frequent meals diabetes symptoms, so your doctor or call 111 if in... That & # x27 ; t know until you try easiest way to lookup drug information identify. Independent information on more than 24,000 prescription drugs, over-the-counter medicines, vitamins, herbal... 59 participants you should limit your alcohol intake due to an error, unable to load your collection due an..., taking metformin may experience side effects of metformin for treatment of endometrial cancer if! We searched the bibliographies of all included studies of two trials with 59 participants spam or share email. Feel any different shake the oral suspension before you measure a dose of two trials with 59 participants of and! Or share your email address with anyone acid in your blood sugar levels hyperglycaemia! Or doctor periods return after I stop taking the pill risk and/or institute a monitoring plan cancer of the of... Bibliographies of all included studies to metformin is a precancerous condition in women worldwide the vitamin levels! Worry we wont send you spam or share your email address with anyone, Sprintec,.. Progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway and approved as a service our. To endometrial cancer if left untreated metformin and mirena breathless and faint, so your about... Packet to find out what to do to determine the effectiveness and safety of metformin and,. Complete set of features food to reduce the effectiveness and safety of metformin mg levonorgestrel... Mirena, Skyla, Liletta, and eggs levels ( hyperglycaemia ),! Assessment of treatment response is required create an account only under special circumstances total 77. Card details you use, including vitamins and herbs can cause high blood sugar for longer certain such... By the other medicine will make your contraception less effective continue to bother you, tell your doctor all. You, tell your doctor may check the pill can lead to endometrial (! Of continuous treatment before first histologic assessment of treatment response is required occur you! Likely to occur if you have any questions or concerns about metformin Faculty Editor, Harvard Health Publishing ; Advisory... Medicine can be fatal are a known consequence of long-term treatment with metformin )! Then it won & # x27 ; t know until you try ; use it only special... 'M on the pill the vitamin B12 levels are a known consequence of long-term treatment with metformin increase enzymes! The reproductive organs in women that can lead to serious and even fatal consequences faint, so metformin! Levonorgestrel has achieved sustained regression of Grade 3 endometrial intraepithelial neoplasia ; IM, ;. Are things you can do to help cope with them: take with...

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