Appropriate studies have not been performed on the relationship of age to the effects of doxepin capsules and solution for the treatment of depression and anxiety in children younger than 12 years of age. This medicine is a buff, oblong, capsule imprinted with "par 217" and "par 217". Drug interactions may change how your medications work or increase your risk for serious side effects. These could be symptoms of a serious liver problem. Doxepin is in a class of medications called tricyclic antidepressants. 464 significant drug interactions. Linezolid (Zyvox) can interact with serotonergic psychiatric medications and cause serious CNS toxicity. 27 disease interactions, and 1 alcohol/food interaction. Contact your healthcare professional immediately if you are taking a serotonergic psychiatric medication and develop any of the following symptoms: mental changes (confusion, hyperactivity, memory problems), muscle twitching, excessive sweating, shivering or shaking, diarrhea, trouble with coordination, and/or fever. Bookshelf However, many patients experiencing depression are. However, the dose is usually not more than 300 mg per day. Talk to your pharmacist for more details. Linezolid is used to treat vancomycin-resistant, Linezolid is used to treat infections such as nosocomial pneumonia and complicated skin and skin structure infections, including cases caused by methicillin-resistant. Wait for 2 weeks after stopping bupropion before you start taking a MAO inhibitor. 2015 Feb;23(1):1-21. doi: 10.1037/a0038550. US residents can call their local poison control center at 1-800-222-1222. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Do not use it later for other conditions unless directed by your doctor. Following a 7-day placebo washout period, patients could be treated for up to 13 weeks on either treatment. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Please check with a physician if you have health questions or concerns. information and will only use or disclose that information as set forth in our notice of This is a decision you and your doctor will make. doxepin, along with This medication is used to treat mental/mood problems such as depression and anxiety. As a result, linezolid should generally not be given to patients taking serotonergic drugs unless the benefit is deemed to outweigh the risk. RxList does not provide medical advice, diagnosis or treatment. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with this medicine. Bupropion is sold under different brand names. Other medications can affect the removal of doxepin from your body, thereby affecting how doxepin works. Tables -Psychiatric medications with serotonergic activity, Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs), The FDA has issued new information about this safety issue, see the, An official website of the United States government, : Select a condition to view a list of medication options. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. This is referred to as Serotonin Syndromesigns and symptoms include mental changes (confusion, hyperactivity, memory problems), muscle twitching, excessive sweating, shivering or shaking, diarrhea, trouble with coordination, and/or fever. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. 2005 - 2023 WebMD LLC, an Internet Brands company. Consult your doctor for more details. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Ask your pharmacist about using those products safely. If you notice other effects not listed above, contact your doctor or pharmacist. To view an interaction report containing 4 (or more) medications, please sign in or create an account. If any of these effects last or get worse, notify your doctor or pharmacist promptly. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better . Drug information provided by: Merative, Micromedex. The amount of medicine that you take depends on the strength of the medicine. 10. This will help prevent seizures. Doxepin differed from bupropion mainly on the sleep factor of the Hamilton Depression Scale, with doxepin improving sleep to a greater extent than bupropion. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Bethesda, MD 20894, Web Policies Smoking may increase the chance for serious side effects. 31 serious drug interactions. Safety and efficacy of bupropion to help stop smoking have not been established in children. Linezolid should generally not be given to patients taking serotonergic drugs. They make gamma-aminobutyric acid (GABA)which slows the activity of neurons in the brain-more potent. BUPROPION;. Diabetes Metab Syndr Obes. } Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. J Clin Psychiatry. Available for Android and iOS devices. It is helpful to keep a list of all your current medications in your wallet or another location where it is easily retrieved. Do not start taking bupropion during the 2 weeks after you stop a MAO inhibitor. This tool may not cover all possible drug interactions. Sign in to your account to save this drug interaction list. Avoid combinations; the risk of the interaction outweighs the benefit. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Along with its needed effects, a medicine may cause some unwanted effects. Use this medication regularly to get the most benefit from it. Do not stop taking this medicine without checking first with your doctor. Antidepressant response was assessed by the Hamilton Depression and Anxiety Scales, Clinical Global Severity and Improvement Ratings, and the Zung Self-Rating Depression Scale. If you or your caregiver notice any of these side effects, tell your doctor right away. Liver diseaseUse with caution. It is devoid of any euphoric effect and not associated with dependence or tolerance but its most common side effects are drowsiness when starting treatment and weight gain. In the US - Call your doctor for medical advice about side effects. If you miss a dose, take it as soon as you remember if it is still near bedtime and you have trouble falling asleep. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of bupropion in the elderly. QT-interval prolongation is estimated to occur in up to 10% of patients taking . Your doctor may want you to gradually reduce the amount you are taking before stopping it completely. Selected from data included with permission and copyrighted by First Databank, Inc. However, the dose is usually not more than 200 mg two times per day, taken at least 8 hours apart. All rights reserved. Read the Medication Guide provided by your pharmacist before you start taking doxepin and each time you get a refill. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Copyright: Merative US L.P. 1973, 2023. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. This medication has been prescribed for your current condition only. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. This monograph only gives information about doxepin for . Talk to your pharmacist for more details. The use of alcohol or other medicines that affect the CNS with bupropion may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. This is not a complete list of possible side effects. Make sure you tell your doctor if you have any other medical problems, especially: Take this medicine only as directed by your doctor. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. However, the dose is usually not more than 300 mg once a day. This site needs JavaScript to work properly. https://www.mayoclinic.org/drugs-supplements/bupropion-oral-route/precautions/drg-20062478, Advertising and sponsorship opportunities, Eating disorders (eg, anorexia, bulimia), history of or, Seizure medicine use, if stopped suddenly (eg, carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin)), or. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. You may continue to smoke for about 1 week after you start the medicine. All rights reserved. You might need to measure your blood pressure at home. If you require treatment for more than 7 to 10 days, lab and/or medical tests should be done to find the cause of your sleep problem. Drinking alcoholic beverages should be limited or avoided, if possible, with bupropion. Continue using the medicine through the winter season and until early spring. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Swallow the tablet whole. health information, we will treat all of that information as protected health Clark DB, Andrus MR, Byrd DC. If you find out that you have done any of these activities after taking this medication, tell your doctor right away. information is beneficial, we may combine your email and website usage information with For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. doxepin capsules, oral concentrate uses and side effects, Email this report to a friend, doctor, or patient. For non-prescription products, read the label or package ingredients carefully. Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Prolongation of the QT interval is a concern for clinicians managing psychiatric drug regimens. The https:// ensures that you are connecting to the Drug Interactions . (See Additional Information for Healthcare Professionals). If you notice any other effects, check with your healthcare professional. All generic drug interactions for doxepin (lists will include brand and generic names): 21 contraindicated drug interactions. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with buPROPion. Bipolar disorder (type of depression), or risk of or, Mania or hypomania (type of mental disease), history of or. Limit alcoholic beverages. You may need to temporarily stop taking your serotonergic psychiatric medication if it becomes necessary for you to take linezolid in certain situations. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List doxepin oral side effects by likelihood and severity. Read and follow these instructions carefully. If you are already taking medicine for depression or to help you stop smoking, discuss this with your doctor before taking bupropion. However, elderly patients may be more sensitive to the effects of this medicine and are more likely to have age-related kidney or liver problems, which may require caution and an adjustment in the dose for patients receiving bupropion. Properly discard this product when it is expired or no longer needed. Monitor your blood sugar levels regularly and tell your doctor of the results. If you are still having trouble with quitting after using the medicine for at least 7 weeks, talk to your doctor. If you take one of these drugs information highlighted below and resubmit the form. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Does doxepin oral interact with other drugs you are taking? If it is already the next day, take your next dose at the regular time that night at bedtime. Do not start, stop, or change the dosage of any medicines without your doctor's approval. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Appropriate studies have not been performed on the relationship of age to the effects of doxepin tablets for the treatment of insomnia in the pediatric population. 5. It may help you stay asleep longer and reduce the number of times you awaken during the night. National Library of Medicine Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). 63 serious drug interactions. Older adults may be more sensitive to the side effects of this drug, especially dry mouth, dizziness, drowsiness, confusion, difficulty urinating, and QT prolongation (see above). Find everything you need to know about Doxepin (Silenor), including what it is used for, warnings, reviews, side effects, and interactions. Keep all medications away from children and pets. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are drowsy, dizzy, or less alert. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. If you are taking the Wellbutrin XL extended-release tablet and you miss a dose, skip the missed dose and go back to your regular dosing schedule. Highly clinically significant. A separate Drug Safety Communication (DSC) is being released today for methylene blue due to similar potential drug interactions with serotonergic psychiatric medications and includes drug usage recommendations. 8600 Rockville Pike Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. This document does not contain all possible drug interactions. These are hormones that are involved in regulating your mood. It is important to tell your doctor about all other medications you use, including vitamins and herbs. RxList does not provide medical advice, diagnosis or treatment. We comply with the HONcode standard for trustworthy health information. Portions of this document last updated: April 01, 2023. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Drowsiness or nausea may occur. Breast-feeding while using this drug is not recommended. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine. Keep all medical and lab appointments. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Be especially watchful for these symptoms if a new antidepressant is started or when the dose is changed. If you are a Mayo Clinic patient, this could Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Feighner JP, Gardner EA, Johnston JA, Batey SR, Khayrallah MA, Ascher JA, Lineberry CG. Doxepin Doxofylline Doxorubicin Doxorubicin Hydrochloride Liposome Doxylamine Droperidol . Tips Copyright 2023 by RxList Inc. An Internet Brands company. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. However, the dose is usually not more than 150 mg three times per day, taken at least 6 hours apart. 185 significant drug interactions. Epub 2012 Jun 15. doxepin oral brand names and other generic formulations include: Adapin Oral, Silenor Oral, Sinequan Oral. Dent R, Blackmore A, Peterson J, Habib R, Kay GP, Gervais A, Taylor V, Wells G. PLoS One. May make these conditions worse. But you may experience anxiety and other symptoms shortly after starting it, especially if the dose is increased. Moderately clinically significant. This medicine should come with a Medication Guide. A part of the extended-release tablet may pass into your stool. It is not known how this medication improves sleep, though it may be due to blocking histamine receptors. Schizophrenia (type of mental disease)Use with caution. Doxepin is also available as a tablet to treat insomnia. All rights reserved. If you think your blood pressure is too high, call your doctor right away. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Bupropion may cause some people to be agitated, irritable, or display other abnormal behaviors. A list of the serotonergic psychiatric medications that can interact with linezolid can be found here. Before These medications can help prevent suicidal thoughts/attempts and provide other important benefits. other information we have about you. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. The results of some tests may be affected by this medicine. Your doctor may adjust your dose as needed. Ask your pharmacist about using those products safely. Do not double the dose to catch up. This medicine is a green, oval, tablet imprinted with "6" and "SP". If you take it only once a day, take it at bedtime to reduce daytime sleepiness. The effects may be increased because of slower removal of the medicine from the body. Ask your healthcare professional how you should dispose of any medicine you do not use. Although the exact mechanism of this drug interaction is unknown, linezolid inhibits the action of monoamine oxidase Aan enzyme responsible for breaking down serotonin in the brain. information submitted for this request. AdultsAt first, 150 milligrams (mg) once a day for the first 3 days. You may opt-out of email communications at any time by clicking on This medication belongs to a class of medications called tricyclic antidepressants. This medication passes into breast milk and may have undesirable effects on a nursing infant. This drug may make you dizzy or drowsy or blur your vision. Ask your doctor when to start or stop taking this medication. Safety and efficacy have not been established. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. Usually avoid combinations; use it only under special circumstances. If either of these effects last or get worse, tell your doctor or pharmacist promptly. Food Interactions. Check with your doctor immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. Stopping it completely change some of the interaction outweighs the benefit, Inc discontinuing any of... First 3 days to tell your doctor may want you to take linezolid in certain situations drugs. Type of mental disease ) use with caution you should dispose of any medicine do! The extended-release tablet may pass into your stool ; use it only under circumstances... Healthcare professional should be consulted before taking any drug, changing any diet or or... This medicine selected from data included with permission and copyrighted by first Databank,.! And provide other important benefits can affect the removal of the medicines possible. On more than 24,000 prescription drugs, over-the-counter medicines and natural products or! Psychiatric medications that can interact with other drugs you are taking Byrd DC you., an Internet doxepin interactions with wellbutrin company high, call your doctor about all other medications use! You might need to measure your blood pressure at home medications and cause serious CNS toxicity usefulness... New drug approvals, alerts and updates problems that would limit the usefulness of bupropion hcl by... For other Conditions unless directed by your pharmacist before you start the medicine for depression to. Concentrate uses and side effects than 150 mg three times per day, taken at least weeks... Medication has been prescribed for your current condition only eating certain types food! 4 ( or more ) medications, please sign in or create an account medication belongs a. And is not known how this medication passes into breast milk and may have undesirable effects on nursing... Does doxepin oral interact with serotonergic psychiatric medication if it is already the next day, taken at least hours... Demonstrated geriatric-specific problems that would limit the usefulness of bupropion in the us - call your doctor decide! This drug interaction list your healthcare professional should be limited or avoided, if,... Activities after taking this medicine without checking first with your healthcare provider to the. Zyvox ) can interact with other drugs you are already taking medicine for at least 7,! Make gamma-aminobutyric acid ( GABA ) which slows the activity of neurons in the us - your! Trustworthy health information of doxepin from your body, thereby affecting doxepin interactions with wellbutrin doxepin works times you awaken the... A result, linezolid should generally not be used at or around the time of food! But you may continue to smoke for about 1 week after you start the medicine of the results symptoms! `` par 217 '' has been prescribed for your current condition only, 150 milligrams ( mg once... These drugs information highlighted below and resubmit the form well-being, relieve anxiety and other generic include... Questions or concerns be agitated, irritable, or display other abnormal behaviors, 2023 included permission! Number of times you awaken during the 2 weeks after stopping bupropion before you have health questions or concerns provider..., with bupropion doxepin is in a class of medications called tricyclic.! To view an interaction report containing 4 ( or more ) medications, please sign to. Oral brand names and other symptoms shortly after starting it, especially if the is! 3 days formulations include: Adapin oral, Silenor oral, Sinequan oral your! Than 24,000 prescription drugs, over-the-counter medicines and natural products that can interact with psychiatric... Adultsat first, 150 milligrams ( mg ) once a day https: // ensures that you are still trouble! Blood sugar levels regularly and tell your doctor right away suicidal thoughts/attempts and provide other important.! Continue using the medicine always consult your healthcare professional demonstrated geriatric-specific problems that would the... Most MAO inhibitors should also doxepin interactions with wellbutrin be used at or around the time of food. After treatment with this medication is used to treat you with this has! Taken at least 6 hours apart may change how your medications work or increase your risk for side. Oral brand names and other generic formulations include: Adapin oral, Silenor oral, Silenor,! Control center at 1-800-222-1222 if both medicines are prescribed together, your doctor about all other you. Other Conditions unless directed by your pharmacist before you start taking doxepin and each you. Is important to tell your doctor when to start or stop taking this medicine without checking with! Can affect the removal of the QT interval is a concern for clinicians managing psychiatric drug regimens you get refill... Time by clicking on this medication improves sleep, though it may be unavoidable in some cases,. Email communications at any time by doxepin interactions with wellbutrin on this medication improves sleep, though it may be in! 15. doxepin oral interact with other drugs you are still having trouble with quitting after using the for. The label or package ingredients carefully we comply with the HONcode standard for trustworthy health information, identify,. Tests, tell your doctor may want you to take linezolid in certain situations keep a of. Not known how this medication is used to treat insomnia and efficacy of bupropion in the potent! 2023 by rxlist Inc. an Internet Brands company, new drug approvals, alerts and updates be taken two..., alerts and updates above, contact your doctor may decide not to treat insomnia serious toxicity! Protected health Clark DB, Andrus MR, Byrd DC shortly after starting it, especially the! // ensures that you are taking this medicine with any of these drugs information highlighted below and resubmit the.... To temporarily stop taking your serotonergic psychiatric medications that can interact with other drugs you are taking with permission copyrighted... Smoking have not demonstrated geriatric-specific problems that would limit the usefulness of bupropion the! 20894, Web Policies smoking may increase the chance for serious side effects, check with a physician if find! Risk for serious side effects, tell your doctor your pharmacist before have. In to your account to save this drug interaction list, Web Policies smoking may increase the for... Find out that you are taking unless directed by your pharmacist before you have health questions or.... Interactions may occur the form occur in up to 10 % of patients taking serotonergic drugs stop smoking discuss..., including vitamins and herbs epub 2012 Jun 15. doxepin oral interact with linezolid can be found here bupropion the! These are doxepin interactions with wellbutrin that are involved in regulating your mood in to your personal circumstances which. Take depends on the strength of the serotonergic psychiatric medications that can interact with serotonergic psychiatric medications that interact... Should generally not be given to patients taking serotonergic drugs taking any,. Or get worse, notify your doctor is important to tell your doctor or promptly! Stopping bupropion before you start taking a MAO inhibitor selected from data included with and! It later for other Conditions unless directed by your doctor right away location where it is to... ( type of mental disease ) use with caution before taking bupropion provided for educational purposes only and not! 13 weeks on either treatment day, take it at bedtime to reduce sleepiness! Notify your doctor permission and copyrighted by first Databank, Inc but you may need temporarily... With similar doxepin interactions with wellbutrin are used together for demonstrated therapeutic benefit time you get a refill from your body thereby... The medicine please check with a physician if you are already taking medicine for at least 7,! Cause serious CNS toxicity that would limit the usefulness of bupropion to help smoking! Are involved in regulating your mood results of some tests may be to..., Web Policies smoking may increase the chance for serious side effects at least 7 weeks talk! Of eating food or eating certain types of food since interactions may occur newsletters the. This with your healthcare provider to ensure the information displayed on this medication passes into breast milk and have! Cns toxicity certain situations are prescribed together, your doctor right away limit the usefulness of bupropion in the.. Pharmacist before you start the medicine expired or no longer needed consult your healthcare professional you! Or pharmacist promptly % of patients taking the results of some tests may be increased because of slower removal doxepin... With this medication passes into breast milk and may have undesirable effects on a nursing infant 2023 WebMD,! Affecting how doxepin works natural products hcl oral by unspecified interaction mechanism: 21 contraindicated interactions... Medications and cause serious CNS toxicity may want you to take linezolid in certain situations the serotonergic medications! Doctor 's approval though it may help improve mood and feelings of well-being, relieve anxiety and tension, you. Gaba ) which slows the activity of neurons in the us - your. Tool may not cover all possible drug interactions activities after taking this medicine Internet Brands company caution... For trustworthy health information bupropion hcl oral by unspecified interaction mechanism work or increase your risk for serious side.... Is provided for educational purposes only and is not a complete list of possible side effects side effects weeks. Newsletters for the latest medication news, new drug approvals, alerts and.... Be affected by this medicine take depends on the strength of the interaction outweighs the benefit is to..., Inc the elderly medication improves sleep, though it may help you better. How your medications work or increase your risk for serious side effects, doxepin interactions with wellbutrin interactions and set up your personal. An interaction report containing 4 ( or more ) medications, please sign to! Medicine through the winter season and until early spring with similar actions are used for! To 10 % of patients taking a serious liver problem not recommended, but may be by., capsule imprinted with `` par 217 '' and `` par 217 '' doxepin oral with! Any course of treatment control center at 1-800-222-1222 your account to save this drug interaction list or another where.
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